article_1753511_1790671330 1790671330 Kıbrıs Ruh Sağlığı Enstitüsü Cyprus Turkish Journal of Psychiatry and Psychology KTPP Dergisi 1302-7840 09 07 2026 8 3 Merve Yurt BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0009-0005-8177-4474 Merve Şahin Can BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-4985-5689 Emrah Özcan BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-6373-4744 Aslıhan Çetinel BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0009-0002-2767-9175 Esma Gül BALIKESİR ÜNİVERSİTESİ, İVRİNDİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU https://orcid.org/0000-0001-6234-937X Ömür Karaca BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-8218-8881 İlter Kuş BALIKESİR ÜNİVERSİTESİ, TIP FAKÜLTESİ https://orcid.org/0000-0002-3194-267X Scientific studies in the literature have demonstrated olfactory loss and reduced olfactory bulb volume in individuals with major depressive disorder. This study aims to evaluate the correlation between major depressive disorder and olfactory region volume. In the study, Magnetic Resonance İmaging (MRI) images of 33 patients with major depressive disorder and 33 healthy controls from Balıkesir University Hospital's Mental Health Clinic were retrospectively analyzed. In the obtained MRI series, the volumes of the amygdala, fusiform gyrus, anterior commissure, olfactory radiation, and entorhinal area, which are involved in olfaction, were measured using a parcellation method. All data were transferred to SPSS and analyzed quantitatively. The statistical analysis of the variables examined in the study revealed that the right and left amygdalae tend to be smaller in individuals with illness. It was determined that there was a positive correlation among the parameters evaluated in the study: left amygdala, left entorhinal area, right and left fusiform gyrus volumes, and the Hamilton Depression Scale. As a result of the research, it was revealed in the direction of morphometric analysis that there is a negative relationship between major depressive disorder and olfactory regions. The data obtained in light of these findings will contribute to understanding the cause-and-effect relationship between depression and loss of smell; for clinicians, it is expected to serve as a guide in diagnosis and treatment. 09 09 2026 12 03 2025 236 243 10.35365/ctjpp.26.3.01 https://dergipark.org.tr/en/doi/10.35365/ctjpp.26.3.01 Abdelmotaleb, M. A. M., Fadeel, N. A., Abdel Naem, M. M., & Said, H. M. (2020). Sociodemographic and clinical characteristics of a sample of patients with major depressive disorder. Minia Journal of Medical Research, 31(2), 8–11. https://doi.org/10.21608/mjmr.2022.220825 Ahmed, H. U., Hossain, M. D., Aftab, A., Soron, T. R., Alam, M. T., Chowdhury, M. W., & Uddin, A. (2017). Suicide and depression in the World Health Organization South-East Asia region: A systematic review. 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